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Despite the fact that this chat will take place in #veteran, it will be accessible to all who want to join via the following link: Imagine a naturally occurring poison – known to cause liver cancer – which 4.5 billion people around the world are chronically exposed to.
Aflatoxins are known hepatocarcinogens, meaning they cause liver cancer, and are considered a Class 1 carcinogen by the International Agency for Research on Cancer, part of the UN World Health Organization.
Thermo Fisher Scientific will donate gene synthesis services, encoding player designs through its proprietary DNA synthesis platforms. M.; Aggarwal, D., Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Through Foldit (run from University of Washington and Northeastern University), anyone in the world can help to optimize an enzyme that we hypothesize could be capable of degrading a susceptible lactone ring in aflatoxin. Chemical degradation of this lactone ring has been demonstrated to decrease aflatoxin toxicity by more than 20-fold. Indian Journal of Advances in Chemical Science 2014, 3, 49-60. Liu, Y.; Wu, F., Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Liver cancer is the third leading cause of cancer death globally, with 83% of cases occurring in East Asia and sub-Saharan Africa. E.; Bhatnagar, D., Challenges facing the biological control strategy for eliminating aflatoxin contamination.
Beyond liver cancer, aflatoxins are associated with worsened health outcomes in the developing world. When fed to cattle, they transform into a more potent toxin which accumulates in milk.